Purdue University Osteogenesis Imperfecta Research Paper

i need minimum 100 words for each question (total minimum 500 words)

You should read chapter 3 (Osteogenesis Imperfecta) from your Clinical Studies in Medical Biochemistry textbook (by Rosenthal and Glew) then answer the following questions;

1.Why is a bluish discoloration of the sclera a common finding in type I OI ?

2.Examination of type I collagen from a patient with type IV OI revealed normal electrophoretic mobility but altered thermal stability. Which region of the molecule is likely to contain the mutation ?

3.Why do mutations in C-propeptides cause significant posttranslational overmodification of type I collagen ?

4.Why does a reduction of collagen thermal stability by 6°C prevent incorporation of the corresponding mutant molecules into bone matrix ?

5.A teenager with a history of fractures but no skeletal deformities and no acute dis- tress was diagnosed with moderate type IV OI. After learning that radiographic analysis revealed low bone mineral density in their child, the parents inquired about a possibility of bisphosphonate therapy. How would you respond to their inquiry ?

make sure to include the reference from the reading assigemnt. Attached is chapter 3.

Also please follow the rubric